Observation: As Jesus explains the challenges of following him, Peter is quick to point out that he and the other disciples have given up everything in their lives to follow Jesus. Jesus responds with this statement, which sounds like a reward ... but may not be.
Yes, Jesus promises eternal life. However, his promise of "a hundred times more" is a double-edged sword. It includes all that has been given up, yet they all come "with persecutions". These would be potentially the same earthly hardships that go into accumulating earthly wealth. In other words, as a follower, you may have the potential for more 'stuff', but you also have the same potential for the same roadblocks, issues, and impediments that make earthly riches difficult and dangerous in the first place.
In context then, this is a warning as much as a promise. Peter is seeking reward for his sacrifices. Jesus is pointing out that his reward will be in heaven, however if he tries to pursue earthly riches while also being a believer, he may be very successful, but the hardships that come along with such pursuits will be equally increased. It would be better to humbly follow Jesus - just like the children in verses 13-16 - than to be the rich young man in verses 17-22 who was desiring to both follow Jesus and have earthly wealth.
Application: This warning has applied directly to my life. My greatest earthly persecution came as a direct outcome of achieving my career goal. There is no possibility of disassociating this message of Jesus from how my professional life and faith have interplayed. As a believer, pursuing earthly goals is ... problematic at best.
Over and over, I ask the Lord for a professional direction I can pursue. His response is becoming clearer and clearer ... that I have a direction, but it is not important that I know it nor that I try to pursue it. He has my direction. He knows my path. If I just hold his hand and walk with him, all will be well.
Prayer: Lord, I do place my life into your hands. It is all I desire to humbly walk with you, my Lord. May I grow in faith enough to no longer care about knowing my path, for thou art with me. Amen.