Observation: Peter and John have been released after being punished for their preaching, and the prayer they declare includes this line. They know that persecution against believers will continue, for even the leaders plotted against Jesus - the anointed Messiah - himself.
However, where is the evidence of such plotting by Herod and Pilate? In the four gospels, at no time does Herod plot against Jesus ... he desires to see him when he is arrested and is disappointed that Jesus will not answer his questions, but has no say in his crucifixion. Likewise, Pilate is never stated to be involved in any of the conversations to arrest Jesus or in any way oppose his ministry, and while he does sentence Jesus to death he does so by coercion of the priests, not apparently on the advice of any Gentiles or "people of Israel". Furthermore, there is no indication that Herod and Pilate ever "met together" and even discussed Jesus at any point.
So, if these events did not take place before Jesus was crucified ... they must have taken place afterward. In fact, we know Herod and Pilate did meet afterward, for at one point we are told that the situation involving Jesus improved their relationship. In addition, the movement of the Church in Jerusalem has not gone unnoticed as it now involves several thousand people, and certainly both rulers would have discussed what (if anything) to do about this new sect. They would have consulted their advisors - both Roman officials and Jerusalem city leaders - and shared their opinions with each other.
Therefore, when the Church says that Herod and Pilate conspire against Jesus, they are really saying that the conspiracy is against those who believe in Jesus as Messiah. The Church is, indeed, the body of Christ, and Christ is the son of God. In this manner, a plot to destroy the Church is a plot against Yahweh.
And how does the Church wish to respond to this threat? As stated in verses 29-30, they wish to be given even more boldness to preach the gospel, and to be able to heal and serve others out of an overflow of their love and generosity to all in the world.
Application: Today, "Herod and Pontius Pilate" can be replaced by any number of leaders who desire control and power, from government officials to leaders of movements and ideals, all of which oppose the teachings of Jesus. They conspire and coordinate - sometimes overtly, sometimes simply by programmatic alignment - in a manner that opposes the Church, condemns faith, and dismisses Jesus. Just like Herod and Pilate, they even hide behind good-sounding ideals, then convincing the masses that faith in Jesus is somehow opposed to the public good.
How should I respond to this? How should all of us who believe in Jesus respond to the threats and hate and lies poured out upon us by those who are deceived by satan to oppose the Lord?
We should love others, serving and caring for them. We should use our resources to offer kindness to all. We should desire to continue to help the downtrodden, even seeking miraculous healing for those who don't believe. And above all, we should continue to simply declare the good news of salvation by faith in Jesus.
Prayer: Lord, loving others is one of the hardest things to do as a Christian, which is probably why it was the key command Jesus personally declared. May I find ways to love others today, even if those individuals live in a manner that supports opposition to my faith and knowledge of Jesus. Amen.